Shradha Mukherjee

Nicknames: Shredder, a supervillain for villains and Goldy, a superhero for heroes.

"Dubito Ergo Cogito; Cogito Ergo Sum" (Latin)
"I doubt therefore I think; I think therefore I am" (English)
-quote by René Descartes.
ref: https://www.bbc.co.uk/programmes/p02pdc6n

About me

I am a scientist. I am interested in and a good fit for computational research spanning multiple scientific disciplines. My education includes graduate level degrees in chemistry, biochemistry and computation (health informatics). My research publications as first and/or corresponding author (2013-present) are in domains of neuroscience, neurological diseases, cancers, stem cells, neurotoxicity and heavy metal toxicity. These publications utilised techniques of molecular biology, biochemistry, bioinformatics, genomic/omics, statistics, machine learning, AI, natural language processing and network analysis. I have published papers (2013-present) in and reviewed papers (2020-present) for, @Nature https://www.nature.com/siteindex, @FrontiersIn https://www.frontiersin.org/journals and @ElsevierConnect https://www.elsevier.com/products/journals (Cell Press) tier 1 highly cited high impact family of journals in addition to others.

Hands-on fairwissenschaft: I do consultancy in UK, EU, Switzerland, Australia, New Zealand, Canada, Japan, South Korea, Singapore and China only.

Effective communication and collaboration are at the heart of my consulting approach. Having worked effectively in teams, I understand the importance of clear and concise communication. My research background has honed my ability to convey complex ideas and technical information in a concise and accessible manner. This skill ensures seamless collaboration with your team, fostering a productive and harmonious work environment. I am confident that my skill set and research experience make me an ideal candidate to contribute to your organization's success. My enthusiasm for problem-solving, coupled with my strong work ethic, ensures that I will deliver exceptional results. Let's embark on this consulting journey together and unlock the potential of your organization. I am excited to discuss how my skills can align with your goals and create tangible value

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Education

MS IN COMPUTATION (HEALTH INFORMATICS), DR. ROBERT GREENES THESIS ADVISOR, ARIZONA STATE UNIVERSITY, TEMPE, U.S., CGPA 3.6 BEST POSSIBLE CGPA 4.0 — YEARS 2017-2019
MS IN CHEMISTRY, INDIAN INSTITUTE OF TECHNOLOGY, CHENNAI, INDIA, CGPA 7.63 BEST POSSIBLE CGPA 10.0 — YEARS 2003-2005
BS IN CHEMISTRY (3 YRS), BOTANY ZOOLOGY (2 YRS), PHYSICS (1 YR), FERGUSSON COLLEGE, PUNE, INDIA, TOTAL SCORE 2456 OUT OF 3100, REQUIRED PASSING SCORE 1240 OUT OF 3100 — YEARS 2000-2003
CERTIFICATE IN MANAGEMENT COURSE 'MANAGING THE COMPANY OF THE FUTURE', UNIVERSITY OF LONDON, LONDON BUSINESS SCHOOL — YEAR 2019
PHD IN BIOCHEMISTRY, UNIVERSITY OF HOUSTON, HOUSTON, U.S., CGPA 3.9 BEST POSSIBLE CGPA 4.0. — YEARS 2005-2011
PHD first author thesis work (link to copy of my thesis on open science HAL archive: https://hal.science/hal-04084217).

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Jobs

Full stack web developer, European Molecular Biology Laboratory- European Bioinformatics Institute, London, U.K. — 2022
Database Management, Development of Python CLI, Web Development.
STAFF, UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, U.S. — 2018-2021
Molecular biology and bioinformatics experiments in field of neurological diseases. During Covid when labs were closed did patient screening at the hospital.
POSTDOCTORAL FELLOW, UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, DALLAS, U.S. — 2011-2017
Molecular biology and bioinformatics experiments in field of adult brain stem cells.

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Teaching

UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, DALLAS, U.S. — 2011-2017
Mentored high school, undergraduate, graduate, postdoctoral researchers and medical students in molecular biology and bioinformatics skills in the postdoctoral research lab.
UNIVERSITY OF HOUSTON, HOUSTON, U.S. — 2005-2007
Conducted “Introduction to Biology” and “Animal Anatomy and Physiology” lab course for undergraduate students

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Standardised Examinations

TOEFL Score 280 out of 300, U.S. exam. 2004
GRE General Score 1450 out of 1600, U.S. exam. 2004
GATE Chemistry, Percentile Score 81.66 i.e. performance 81.66% BETTER than other candidates who appeared for the exam (top 18% of candidates), India exam. 2005

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Publications And Codes

Publications in paid scientific journals. From complete list of publications, the major authorship (first author and corresponding author) papers are as follows:

Mukherjee S*†. Immune gene network of neurological diseases: Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Heliyon 2021; 7:12. https://doi.org/10.1016/j.heliyon.2021.e08518
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of this 'Publications And Codes' section. Codes for this project are in folder/repository named 'githubsubmittedadpdhdmsimmunesept2021' or 'GithubSubmittedADPDHDMSimmuneSept2021'.
Mukherjee S*†. Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples. Scientific Reports 2020; 10, 10937. https://doi.org/10.1038/s41598-020-67753-5
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of this 'Publications And Codes' section. Codes for this project are in folder/repository named 'githubscientificreportsglioblastomastemapril2020' or 'GithubScientificReportsGlioblastomaStemApril2020'.
Mukherjee S*†, Klaus C†, Pricop-Jeckstadt M, Miller JA and Struebing FL*†. A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. Frontiers in Neuroscience 2019; 13:2. https://doi.org/10.3389/fnins.2019.00002
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of this 'Publications And Codes' section. Codes for this project are in folder/repository named 'githubfrontiersneuroscidec2018' or 'GithubFrontiersNeurosciDec2018'.
Mukherjee S*†. Genomics-Guided Immunotherapy for Precision Medicine in Cancer. Cancer Biotherapy and Radiopharmaceuticals 2019; 10.1089/cbr.2018.2758. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802731 (write-up only as its review article)
Mukherjee S†, Brulet R, Zhang L and Hsieh J*. REST regulation of gene networks in adult neural stem cells. Nature Communications 2016; 7:13360. https://doi.org/10.1038/ncomms13360
Code Availability: See book chapter, Mukherjee S†, Hsieh J*. Genome-Wide Identification of Transcription Factor-Binding Sites in Quiescent Adult Neural Stem Cells. In: Lacorazza H. (eds) Cellular Quiescence. Methods in Molecular Biology, vol 1686. Humana Press, New York, NY (Springer Nature) 2018. https://pubmed.ncbi.nlm.nih.gov/29030827.
Mukherjee S, Hsieh J. On your (methyl) mark, get TET1, go! Cell Stem Cell. 2013 Aug 1;13(2):133-4.PMID: 23910076.https://doi.org/10.1016/j.stem.2013.07.011 (write-up only as its review article)

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Projects And Codes

Code Repositories (Alt.Links): Gitlab | Bitbucket | Github

Projects with codes and write-up are as follows:

Mukherjee S*†. Machine Learning classifier built with heavy metal signature biomarker genes as features to distinguish between heavy metal exposure from non-heavy metal exposure gene expression samples. 2023 https://hal.science/hal-04084188
Please note, this is pre-print of the manuscript, which is under review for publication in a scientific journal.
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of this 'Projects And Codes' section. Codes for this project are in folder/repository named 'pbothers_rnaseq_ml_feb2023' or 'PbOthers_RNAseq_ML_Feb2023'.
COPY OF MY MASTERS (MS) THESIS AS AVAILABLE IN LIBRARY OF ARIZONA STATE UNIVERSITY, U.S.: Mukherjee S*†. Targeted BEL network representation and characterization of commonly mutated genes in Non-Small Cell Lung Carcinoma (NSCLC). 2019 https://hal.science/hal-04084202
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'bmi593_appliedproject_nsclc', 'BMI593_AppliedProject_NSCLC', 'nsclc_drugtargetsmutations_nov2019' or 'NSCLC_DrugTargetsMutations_Nov2019'.
COPY OF MY PHD THESIS AS AVAILABLE IN LIBRARY OF UNIVERSITY OF HOUSTON, U.S.: Mukherjee S*† et. al. Gestational lead exposure shortens cell cycle length and activates developmental molecular network of neurogenesis in postnatal retina. 2011 https://hal.science/hal-04084217
Code Availability: Wet lab research so no codes.

Projects with codes related to papers (write-up) published in paid scientific journals are as follows:

Glioblastome_Drug_Gene_Disease_Database_SQL.
#Citation: Mukherjee S*†. Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples. Scientific Reports 2020; 10, 10937. https://doi.org/10.1038/s41598-020-67753-5
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'glioblastoma_drug_gene_disease_database_sql' or 'Glioblastome_Drug_Gene_Disease_Database_SQL'.
Glioblastoma_Grade_Stem_Cell_Genes_Deconvolution_to_Regression.
#Citation: Mukherjee S*†. Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples. Scientific Reports 2020; 10, 10937. https://doi.org/10.1038/s41598-020-67753-5
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'glioblastoma_grade_stem_cell_genes_deconvolution_to_regression' or 'Glioblastoma_Grade_Stem_Cell_Genes_Deconvolution_to_Regression'.
Neurons_RNAseq_Expression_DESeq2_visualization_GO.
#Citation 1: Mukherjee S*†. Immune gene network of neurological diseases: Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Heliyon 2021; 7:12. https://doi.org/10.1016/j.heliyon.2021.e08518
#Citation 2: Mukherjee S*†. Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples. Scientific Reports 2020; 10, 10937. https://doi.org/10.1038/s41598-020-67753-5
#Citation 3: Mukherjee S*†, Klaus C†, Pricop-Jeckstadt M, Miller JA and Struebing FL*†. A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. Frontiers in Neuroscience 2019; 13:2. https://doi.org/10.3389/fnins.2019.00002
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'neurons_rnaseq_expression_deseq2_visualization_go' or 'Neurons_RNAseq_Expression_DESeq2_visualization_GO'.
StemCells_RNAseq_Expression_edgeR_visualization_GO.
#Citation 1: Mukherjee S*†. Immune gene network of neurological diseases: Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Heliyon 2021; 7:12. https://doi.org/10.1016/j.heliyon.2021.e08518
#Citation 2: Mukherjee S*†. Quiescent stem cell marker genes in glioma gene networks are sufficient to distinguish between normal and glioblastoma (GBM) samples. Scientific Reports 2020; 10, 10937. https://doi.org/10.1038/s41598-020-67753-5
#Citation 3: Mukherjee S*†, Klaus C†, Pricop-Jeckstadt M, Miller JA and Struebing FL*†. A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks. Frontiers in Neuroscience 2019; 13:2. https://doi.org/10.3389/fnins.2019.00002
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'stemcells_rnaseq_expression_edger_visualization_go' or 'StemCells_RNAseq_Expression_edgeR_visualization_GO'.

Projects with codes and write-up that are copyrighted are as follows:

EMBL_EBI_Exams_2022. #Warning: This project is protected by copyright. Copyright © 2022 Shradha Mukherjee for solutions. All rights reserved. Acknowledgement and/or Copyright © 2022 EMBL-EBI for questions.
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'embl_ebi_exams_2022' or 'EMBL_EBI_Exams_2022'.
Glioblastoma_Comorbidities_NLP_May2019 Class Project. #Warning: This project is protected by copyright. Copyright © 2019 Mohamed Mohamed (researcher/communication), Victoria Oladoye (researcher/documentation), Sierra Murray (evaluator/appraisal), Shradha Mukherjee (researcher/scheduling) and Arizona State University for question. All rights reserved.
Code Availability: Yes, please see Code Repositories (5 Alt.Links)' provided at start of 'Projects And Codes' section. Codes for this project are in folder/repository named 'gbothers_nlp_may2019' or 'GBothers_NLP_May2019'.

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